尿液相关细胞因子在系统性红斑狼疮肾脏病情评估中的意义 |
| 吴永卓，曹文婷，邓丹琪 |
| 昆明医科大学第二附属医院皮肤科，云南 昆明 650101 |
Clinical signifi cance of urinary cytokines in the evaluation of kidney damage in systemic lupuserythematosus |
| WU Yong-zhuo,CAO Wen-ting,DENG Dan-qi |
| Department of Dermatology,The Second Affi liated Hospital of Kunming Medical University,Kunming,Yunnan 650101,China |
| 摘要 |
[目的] 目的 明确尿液细胞因子 TNF-α、IL-6 水平在系统性红斑狼疮（SLE）肾脏病情评估中的临床意义。方法 选取 2018年 2 月至 2019 年 2 月在昆明医科大学附属第二医院住院的 SLE 患者 30 例，同期纳入性别、年龄相匹配的非红斑狼疮者 30 例作为对照。采用酶联免疫吸附试验（ELISA）测定患者和对照组的尿 TNF-α、IL-6 表达水平，并收集 SLE 患者的相关临床数据及资料。评估尿 TNF-α、IL-6 水平与 SLE 肾脏病情的关系。结果 相对于对照组，SLE 患者尿中 TNF-α、IL-6 水平明显升高，其差异具有统计学意义；且 SLE 患者尿 TNF-α、IL-6 水平与尿微量蛋白尿肌酐比均呈正相关；SLE 患者尿 TNF-α、IL-6 水平与 SLEDAI 评分均无相关性。结论 检测尿 TNF-α、IL-6 水平在 SLE 患者的肾脏病情评估中有重要意义。 |
| 关键词 |
系统性红斑狼疮 ; 尿 TNF-α ; 尿 IL-6 ; 尿微量蛋白尿肌酐比 ; SLEDAI 评分 |
| Abstract： |
Objective To investigate the clinical signifi cance of urinary cytokines TNF-α and IL-6 levels in the evaluation of kidney damage in sys-temic lupus erythematosus (SLE). Methods The clinical data and urinary sample of 30 SLE patients and 30 healthy controls were collected in the Sec-ond Affi liated Hospital of Kunming Medical University from February 2018 to February 2019. The level of urinary TNF-α and IL-6 was detected usingELISA, and clinical data of SLE patients were collected, so as to evaluate the relationship between urine TNF-α, IL-6 levels and SLE kidney damage.Results Urinary TNF-α and IL-6 levels in SLE patients were signifi cantly higher than those in the control group; Urinary TNF-α, IL-6 and urinemicroalbuminuria-creatinine ratio were positively correlated. There was no correlation between urinary TNF-α and IL-6 levels in SLE patients withSLEDAI score. Conclusion The detection of urinary TNF-α and IL-6 levels is of great signifi cance in the evaluation of renal damage in SLE patients. |
| Keywords |
Systemic lupus erythematosus ; Urinary TNF-α ; Urinary IL-6 ; Microalbuminuria and urinary creatinine ratio ; SLEDAI score |
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