水杨酸联合果酸治疗轻中度痤疮的临床疗效观察 |
| 阙冬梅，梁国雄，杨 娟，唐渝璐 |
| 广东医科大学附属中山医院 / 中山陈星海医院皮肤科，广东 中山 528415 |
Clinical observation on treatment of mild to moderate acne with salicylic acid combined withglycolic acid |
| QUE Dong-mei,LIANG Guo-xiong,YANG Juan,TANG Yu-lu |
| Department of Dermatology,Zhongshan Hospital affiliated to Guangdong Medical University/Zhongshan ChenxinghaiHospital,Zhongshan,Guangdong 528415,China |
| 摘要 |
[目的] 观察水杨酸联合果酸治疗轻中度痤疮的临床疗效及安全性，以及对皮肤 VISIA 检测值的改善情况。方法 纳入 97 例轻中度痤疮患者，随机分为三组，其中治疗组 31 例采用水杨酸联合果酸换肤治疗，果酸对照组 32 例采用果酸换肤单独治疗，水杨酸对照组 34 例采用水杨酸换肤单独治疗。比较三组不同治疗时间点非炎症性痤疮皮损和炎症性痤疮皮损数量、治疗结束时总体有效率、皮肤 VISIA 检测指标的改善情况。结果 治疗结束时治疗组有效率为 74.2%、果酸治疗组有效率为 53.1%、水杨酸治疗组有效率为 55.9%，治疗组与果酸治疗组及水杨酸治疗组比较差异均有统计学意义（x 2 =4.25，P ＜ 0.05；x 2 =5.71，P ＜0.05），但果酸治疗组与水杨酸治疗比较差异无统计学意义（x 2 =2.68，P ＞ 0.05）。治疗 6 周时及治疗结束 4 周治疗组非炎性皮损数量均少于果酸治疗组和水杨酸治疗组，两两比较差异有统计学意义（P ＜ 0.05），而果酸治疗组和水杨酸治疗组比较差异无统计学意义（P ＞ 0.05）。治疗结束 4 周时 VISIA 检测斑点、红斑、紫质值治疗组均小于果酸治疗组和水杨酸治疗组，差异均有统计学意义（P ＜ 0.05），但果酸治疗组和水杨酸治疗组之间差异无统计学意义。果酸和水杨酸治疗无全身不良反应，可出现不同程度水肿性红斑，灼热、刺痛、瘙痒或干燥脱屑等不适，均可耐受，全部患者完成疗程治疗。结论 果酸联合水杨酸治疗轻中度痤疮比单独使用果酸或水杨酸治疗有效率更高，对 VISIA 检测的斑点、红斑、紫质值改善更为明显，可为临床治疗轻中度痤疮提供更有效的选择且安全性好。 |
| 关键词 |
痤疮 ; 轻中度 ; 水杨酸 ; 果酸 ; VISIA |
| Abstract： |
To investigate the clinical effi cacy and evaluate the security in the treatment of mild to moderate acne with salicylic acid com-bined with glycolic acid. While to investigate the improvement in testing index with skin VISIA. Methods 97 patients with mild to moderate acne weredivided into three groups randomly.31 cases in the treatment group was treated with salicylic acid combined with glycolic acid, while 32 cases in the gly-colic acid control group was treated with glycolic acid and 34 cases in the salicylic acid control group was treated with salicylic acid alone. The nonin-fl ammatory lesions, infl ammatory lesions, effi cacy and skin VISIA testing index were compared in different timing. Results At the end of treatment, theeffective rate of the treatment group was 74.2%, the effective rate of the glycolic acid treatment group was 53.1%, and the effective rate of the salicylicacid treatment group was 55.9%，the difference between the treatment group and the glycolic acid treatment group and the salicylic acid treatment groupwas statistically signifi cant (x 2 =4.25，P ＜ 0.05；x 2 =5.71，P ＜ 0.05). Nonetheless the difference was not statistically signifi cant between the glycolic acidcontrol group and the salicylic acid control group(x 2 =2.68,P ＞ 0.05). After 6 weeks treatment and four weeks after treatment the noninfl ammatory le-sions in treatment group were less than the two control groups with statistically signifi cant difference(P ＜ 0.05), however the difference was not statis-tically signifi cant between the glycolic acid control group and the salicylic acid control group(P ＞ 0.05). 4 weeks after the end of treatment, the freckle,erythema value and sclererythrin detected by VISIA of the treatment group were lesser than the two control groups, and the differences were statisticallysignifi cant（P ＜ 0.05）, but no difference between the two control groups. There were not systemic adverse reactions in the treats with glycolic acid andsalicylic acid, but local adverse reactions including edematous erythema, scorching hot, pricking,itching and dry desquamation which could be tolerant.All the patients taking part in the experiment fi nished the treatment. Conclusion It was more effective when mild to moderate acne was treated with sal-icylic acid combined with glycolic acid than only with salicylic acid or glycolic acid, furthermore the improvement was greater in freckle, erythema andsclererythrin tested by VISIA. This method could provide a more effective clinical choice in treating mild to moderate acne with high security. |
| Keywords |
Acne ; Mild to moderate ; Glycolic acid ; Salicylic acid ; VISIA |
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